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Survey Paper | Microbiology | Volume 14 Issue 12, December 2025 | Pages: 1445 - 1450 | India
Bacterial Profile and Antimicrobial Susceptibility Patterns of Isolates Among Patients with Surgical Site Infections at a Tertiary Care Hospital
Abstract: Background: Surgical site infections (SSIs) are among the most common healthcare-associated infections, particularly in low- and middle-income countries. The emergence of antimicrobial resistance has significantly affected the management and outcomes of SSIs. Objectives: To determine the bacterial profile of surgical site infections and to assess the antimicrobial susceptibility patterns of the isolated pathogens. Materials and Methods: A prospective cross-sectional study was conducted in the Department of Microbiology at Hi-Tech Medical College and Hospital, Bhubaneswar, from January 2024 to June 2024. A total of 200 pus samples collected from clinically suspected SSIs in both inpatient and outpatient departments were processed. Samples were cultured on Blood agar and MacConkey agar, and organisms were identified by standard conventional methods. Antimicrobial susceptibility testing was performed using the Kirby?Bauer disk diffusion method on Mueller?Hinton agar, and results were interpreted according to CLSI guidelines. Results: Of the 200 samples, 68 (34.0%) yielded positive bacterial growth. Staphylococcus aureus was the most common isolate (30.9%), followed by Klebsiella pneumoniae (29.4%), Pseudomonas aeruginosa (20.6%), and Escherichia coli (19.1%). High resistance was observed among Gram-negative isolates to amoxicillin-clavulanic acid (94.0%), amoxicillin (94.0%), cefixime (90.7%), and cefepime (89.8%). All Staphylococcus aureus isolates were resistant to ampicillin and amoxicillin but showed 100% susceptibility to linezolid and vancomycin. Conclusion: The study highlights a predominance of multidrug-resistant organisms causing SSIs, emphasizing the need for continuous surveillance, rational antibiotic use, and adherence to antibiotic stewardship programs.
Keywords: Surgical site infection, antimicrobial resistance, bacterial profile, antibiotic susceptibility, tertiary care hospital
How to Cite?: Dr. Nishikanta Sahoo, "Bacterial Profile and Antimicrobial Susceptibility Patterns of Isolates Among Patients with Surgical Site Infections at a Tertiary Care Hospital", Volume 14 Issue 12, December 2025, International Journal of Science and Research (IJSR), Pages: 1445-1450, https://www.ijsr.net/getabstract.php?paperid=MR251218190545, DOI: https://dx.dx.doi.org/10.21275/MR251218190545