Rare Case of Seronegative Neuromyelitis Optica Presenting with Seizure

Dr. Raj Sachde, Dr Subhashchandra K Gadhvicharan, Dr. Girish Kalsariya

Abstract: Neuromyelitis optica spectrum disorder (NMOSD) is a rare autoimmune condition primarily characterized by optic neuritis and longitudinally extensive transverse myelitis (LETM). Seropositivity for aquaporin-4 antibodies (AQP4-IgG) has been considered a hallmark of NMOSD. However, this case presentation focuses on an exceptional case of NMOSD in a 28 year old female presenting with 1st episode of seizure who didn?t exhibit evidence of AQP4-IgG seropositivity. Keywords ? Seronegative Neuromyelitis Optica ? Generalized Tonic-Clonic Seizures.

Keywords: Seronegative Neuromyelitis Optica, Generalized Tonic-Clonic Seizures, Atypical NMO Presentation, AQP4-IgG Negative, Autoimmune Neurological Disorder