Histopathological and Immunohistochemical Correlation of Neoplastic and Non - Neoplastic Lesions of the Ovary: A 1 Year Study in Tertiary Care Hospital

Dr. Nidhi Italiya, Dr. Dimple Sangani, Dr. Arpita Salvi, Dr. Bharat Bhatu

Abstract: Background: The study aimed to comprehensively investigate ovarian lesions through a combined approach of histopathological and immunohistochemical analyses over a one-year period in a tertiary care hospital setting. Ovarian lesions present a spectrum of pathological entities ranging from neoplastic to non-neoplastic conditions, necessitating accurate diagnosis for effective management. Histopathological examination remains the cornerstone for diagnosis, while immunohistochemistry provides valuable adjunctive information, particularly in challenging cases. Aims and Objectives: 1) To analyse the frequency of ovarian lesions. 2) To study histopathology and immunohistochemistry in various ovarian lesion. 3) To provide diagnosis for further management of patient. 4) To use IHC markers in typing and sub typing of malignant ovarian lesions. Methods: A retrospective study was carried out for a period of 12 months. Relevant data collected. Formalin fixed biopsies were processed and stained with H&E stain. Special stain and immunohistochemistry were applied if required. Results: A study of 50 cases was done among which 28 were non neoplastic ovarian lesions and 22 were neoplastic ovarian lesions. Histopathological examination categorised lesions into neoplastic and non-neoplastic categories. Neoplastic lesions included benign, borderline, and malignant tumours, while non-neoplastic lesions encompassed inflammatory and functional cysts. Immunohistochemical staining provided additional diagnostic information, aiding in the characterisation and sub-classification of lesions. Conclusion: The combined approach of histopathological and immunohistochemical analysis proved valuable in accurately diagnosing ovarian lesions, guiding further management strategies. The findings highlight the importance of integrating multiple diagnostic modalities for comprehensive evaluation and optimal patient care in the management of ovarian pathology.

Keywords: Ovarian biopsy and specimen, histopathological examination, immunohistochemistry