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Analysis Study Research Paper | Pharmacy | India | Volume 13 Issue 2, February 2024
One-Pot Synthesis of Novel Imidazoline Amine Derivatives and Evaluation of their Anti Microbial Activity
Mudhurukolla Sudha | Payyaula Naresh [4] | Kandhuri Srinidhi
Abstract: Infections are one of the major reasons for mortality. They cause one fourth of the deaths throughout the world and half of the deaths in developing countries. Since most of the current antibiotics got resistance towards the pathogens, the need for the development of novel antimicrobial agents became a vital task in the medicinal chemistry research. Current study focused on the synthesis and antimicrobial activity evaluation of the novel imidazole derivatives. The synthesis involves a simple one pot reaction between the aryl aldehyde, propane-1,2,3-triamine in the presence of NaI and aq 30% H2O2. The products were purified by column chromatography on silica gel using EtOAc?Hexane (10:1) as eluent. All the synthesized compounds were analysed by IR, NMR and Mass Spectral studies. The designed synthetic scheme delivered the targeted imidazoline amine hybrids in good yields. Analytical characterization with spectral techniques confirmed the structure of the synthesized compounds. Antimicrobial assay employed two gram-positive bacteria: S. aureus and B. subtilis; two gram-negative bacteria: P. aeruginosa, E. coli and two fungal strains - Aspergillus niger and Candida albicans). The agar plate disk diffusion method was used for the antimicrobial assay. The results reveal that all the compounds demonstrated potent antibacterial, antifungal properties especially the compounds 3d and 3e are more potent among the tested compounds.
Keywords: CDCl3, DMSO, LC-MS, PPM, SEM, TMS
Edition: Volume 13 Issue 2, February 2024,
Pages: 621 - 630