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Comparative Studies | Obstetrics and Gynecology | India | Volume 12 Issue 9, September 2023
A Comparative Study of Dinoprostone Gel and Dinoprostone Insert for Induction of Labor at Term Pregnancy
Dr. Ekta [8] | Dr. Lila Vyas | Dr. Ankita Gahlot [2]
Abstract: Aim: The study was done to compare the efficacy of dinoprostone gel and dinoprostone insert for induction of labor. Material and Methods: A hospital-based prospective comparative study was conducted in the Department of Obstetrics and Gynecology, SMS Medical College, Jaipur from April 2018 to November 2018.100 pregnant women at term attending antenatal clinic were enrolled and were divided into two groups, Group-A (intracervical gel) and B (vaginal insert) comprising 50 women in each group. The primary outcomes measured were the number of women progressing to active labori.e. cervical dilation >4 cm, time taken to achieve active labor and need for oxytocin augmentation. Results: In our study, 86.00% women in the gel group and 90.00% in insert group achieved active labor within 24 hours but there was no statistically significant difference between the two groups (P-value >0.05). In Group-A, mean time of induction to active phase was 11.8 ? 2.34 hours in primiparas and 10.8 ? 2.51 hours in multipara. In Group-B, mean time of induction to active phase was 11.42 ? 2.18 hours in primipara and 8.6 ? 2.39 hours in multipara, which was statistically insignificant in gel group but significant in insert group. The need for oxytocin administration was greater in gel group, but the difference was statistically insignificant (p-value= 0.509). A higher number of women failed to achieve a successful induction of labor in gel group as compared to insert group. But the difference was not statistically significant (p = 0.486). Conclusions: In terms of successful induction of labor, dinoprostone vaginal insert is similar to intracervical gel in efficacy. Clinical Significance: Dinoprostone vaginal insert has been introduced only recently in India. Therefore it needs evaluation of efficacy as well as comparison with the conventional intracervical gel preparation for use in the Indian population.
Keywords: labor, dinoprostone, induction
Edition: Volume 12 Issue 9, September 2023,
Pages: 1889 - 1892