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Masters Thesis | Pharmacology and Toxicology | India | Volume 12 Issue 6, June 2023
Nephroprotective Activity of Syzygium Cumini in Gentamicin Induced Nephrotoxicity in Wistar Rats
Dheeraj Kumar Vishwakarma | Vishnu A. Kangralka | Sambrekar SN | Shivani Kumari  | Pawan Kasaudhan
Abstract: Objective: The nephroprotective effects of methanolic extract of Syzygium cumini leaf in rats was investigated1. Method: Nephrotoxicity was induced by using gentamicin 100mg/kg, intraperitoneal for 7 days. Phytochemical test and acute toxicity test of Syzygium cumini leaf were carried out. The methanolic extract of Syzygium cumini leaf were given to these rats at doses level of 250mg/kg and 500mg/kg, per oral for 14 days. Cystone at the dose of 500mg/kg given per oral as standard drug to separate group of rat for 14 consecutive days for comparing nephroprotective activity. Result: Gentamicin induced nephrotoxicity which was indicated by increased levels of serum uric acid, serum creatinine and decreased serum protein along with increased urine urea, urine uric acid, urine creatinine and total protein2. On administration of methanolic extract of Syzygium cumini leaf to albino rats showed significantly decreased in the serum cretinine, serum urea, serum uric acid and increase serum total protein along with decrease urine urea, urine cretinine, urine uric acid, and total protein. These were decrease in malondialdehyde levels and increased levels of catalase, superoxide dismutase, glutathione as compared with gentamicin induced group. In histopathological studies gentamicin induced nephrotoxicity was indicated by degenerative change in kidney tissue, congestion with inflammation. Conclusion: The results showed Syzygium Cumini leaf having nephro protective effect.
Keywords: Nephroprotective activity, Syzygium Cumini, Gentamicin induced nephrotoxicity
Edition: Volume 12 Issue 6, June 2023,
Pages: 1403 - 1406