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Research Paper | Pediatrics | India | Volume 12 Issue 4, April 2023
Assessment of Non-Alcoholic Fatty Liver Disease in Adolescents with Malnutrition: A Cross-Sectional Study
Pawan Nimbhorkar [4] | Rakesh Thamke [4] | Vijay Kamale [4] | Akshai B.
Abstract: Introduction: NAFLD is the most common liver disorder and its increased worldwide prevalence in adolescents is associated with the global obesity epidemic. NAFLD is strongly associated with malnutrition (under nutrition as well as obesity). The prevalence of lean NAFLD or non-obese NAFLD is also increasing. NAFLD has a close association with obesity, CV disease, diabetes mellitus and hepatocellular carcinoma, thus increasing occurrence of NAFLD is a matter of concern, as it is associated with increased morbidity and mortality. Indian data is scarce; therefore, the present study was undertaken to assess NAFLD in adolescents with malnutrition (under nutrition as well as obesity). Objectives: To assess NAFLD in adolescents with malnutrition (under nutrition as well as obesity). Material & Methods: A cross sectional study was conducted at MGM Medical College & Hospital, Navi Mumbai and MGM School, Nerul including 60 adolescents between age group of 12 to 19 years. Demographic details and anthropometric measurements were done for the children with necessary permission before the start of the study. Anthropometry was done using standard guidelines and WHO charts were used for classification of obese and underweight. USG abdomen and biochemical investigations were done for diagnosis of NAFLD. Result: We included 60 study subjects in our study. The average age of study subjects was 18.43?0.78 years ranged from 17 years to 19 years, among which 53.3% (n=32)were females. According to BMI for age, 50% (n=30) of subjects were obeseand50% (n=30) were underweight. Inpatients categorized according to BMI as an obese and underweight group, the SGOT and SGPT levels were significantly associated (p=0.04, p=0.04), whereas USG abdomen findings were not significantly associated (p=0.12). Similarly, in patients categorized according to WHR as normal, obese, and overweight, had a significant association with SGOT, SGPT levels andUSG abdomen findings (p=0.02, p=0.02, p=0.034). Conclusion: BMI and WHR along with biochemical parameters can be used to predict the risk of NAFLD in adolescents in resource-poor setup.
Keywords: Non-alcoholic fatty liver disease (NAFLD), obese adolescents, malnutrition, under nutrition, lean NAFLD
Edition: Volume 12 Issue 4, April 2023,
Pages: 73 - 81