International Journal of Science and Research (IJSR)

International Journal of Science and Research (IJSR)
Call for Papers | Fully Refereed | Open Access | Double Blind Peer Reviewed

ISSN: 2319-7064


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Analysis Study Research Paper | Medical Surgical | India | Volume 12 Issue 1, January 2023


Effect of Acenocoumarol amongst Patients Who Have Undergone Prosthetic Valve Replacement

Dr. Pradeep Anand | Dr. Manimaran | Dr. Vinod Balaji


Abstract: Background: There is a increased risk of thromboembolism in patients with mechanical prosthetic heart valves (MPHV). To reduce the incidence a long term anticoagulant is administered post surgery. As sex based di?erence in these patients is not clear this study was done to study the efficacy of the oral anticoagulant and the sex based di?erence in the patients with MPHV. Methodology: It is a Pre and post-intervention study conducted in the Institute of Cardiovascular and Thoracic surgery, in a tertiary care centre from January 2021 to January 2022. Based on the inclusion and exclusion criteria the sample size recruited during the study time is 100. Demographic details were got from the patient information sheet. ESR and PT INR were done before surgery, after surgery and at the time of discharge. Data was entered in MS Excel 10. Statistical analysis was done in SPSS 23. Continuous data were expressed in terms of Mean?Standard deviation and Categorical variable were expressed in terms of numbers (percentages). P-value of <0.05 is considered as significant. Results: Female preponderance is seen 55%. Majority of our study participants were found to be in 41-50 years of age category. Comorbidities was found to be more in females. Mitral-aortic valve surgery was mostly observed in females. The most common comorbidity observed was Hypertension followed by Diabetes. Age and Number of Comorbidities found to have statistically significant association. Conclusion: In our study, it is found that the female sex has been associated with Mitro-aortic and mitral valve MPHV. High INR, increased ageing and comorbidities plays an important role in the mortality in both sexes.


Keywords: Mechanical prosthetic, mortality, comorbidities, anticoagulant


Edition: Volume 12 Issue 1, January 2023,


Pages: 408 - 411


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