Downloads: 1 | Views: 81 | Weekly Hits: ⮙1 | Monthly Hits: ⮙1
Analysis Study Research Paper | Anaesthesiology | India | Volume 12 Issue 10, October 2023
Evaluation of Early Institution of High Flow Nasal Oxygen Therapy in Type 1 Respiratory Failure in COVID 19 Patients - An Observational Study
Dr. Akanksha Singh [2] | Dr. Shahbaz Ahmed [2] | Dr. Bhavana [4]
Abstract: Background: Type 1 respiratory failure is commonly seen in COVID 19 patients. High flow nasal oxygen was a new concept in management of ARDS. Heated humidified gas up to 37?C at high flow are delivered through nasal cannula using air/ oxygen blender. HFNO reduces the work of breathing by conditioning of gas by warming and humidifying it to physiological conditions. It is reported to be superior than COT and is as effective as NIV in patients with Type 1 respiratory failure. Aim and Objectives: To determine the efficacy of early institution of HFNO therapy on weaning in COVID 19 patients, to observe hemodynamic changes, number of days on and complications of HFNO. Methods: After obtaining institutional Ethical Committee and written informed consent from patients, prospective observational study was conducted on 70 COVID 19 positive patients (rapid antigen kit test or RT- PCR) aged 30-80 years with Type 1 respiratory failure (ABG- PaO2 & PaCO2) at COVID anaesthesia ICU, Nehru Hospital, Gorakhpur. 70 patients screened and put on nasal prongs on admission. 60 people, with mild or moderate ARDS were treated with HFNO. 10 patients with severe ARDS were excluded. Univariate logistic regression analysis was used to explore the association between predictors with risk of intubation. Analysis was done using SPSS software, version 24.0 Result: Out of 60 patients, who were treated with HFNO, 68.3%(41) were weaned off within 7 days, only 8.3%(5) patients required intubation, 11% (7) patients were expired. It was observed that the mean PaO2/ FiO2 ratio improved significantly (p<0.05) from admission (196.74+/- 49.92) to 30 minutes after admission (202.47+/- 49.52). Conclusion: Early institution of HFNO in COVID 19 patients with mild or moderate ARDS showed early and better recovery and patients can be successfully weaned off without requiring mechanical ventilation.
Keywords: High flow nasal oxygen therapy, Type 1 respiratory failure, ARDS management, COVID-19 patients
Edition: Volume 12 Issue 10, October 2023,
Pages: 244 - 248