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Research Paper | Obstetrics and Gynecology | India | Volume 11 Issue 12, December 2022
Role of Platelet Distribution Width and Mean Platelet Volume in Assessment of Severity of Pre Eclampsia - A Prospective Observational Study in Tertiary Care Centre
Dr. R. Rajarajeswari [4] | Dr. Dr. B. Meenambiga | Dr. P. Manju Priya
Abstract: Background: Hypertension and its complications are ranked as a third leading cause of maternal mortality, responsible for 16% of maternal deaths and over half of these hypertension related deaths were preventable. In India the incidence of preeclampsia is reported to be 8 - 10% of the pregnancies. The progression of preeclampsia is evident by decrease in platelet count. This decrease in platelets is compensated by production of premature platelets which in turn leads to normal platelet count but an increase in MPV and PDW. The aim of this study is to assess the changes occurring in platelet indices in patients with pre - eclampsia and establish their role in assessing the severity of preeclampsia and in turn these parameters could be used for early diagnosis of the severity of the disease. Methods: In the present study conducted at Department of Obstetrics and Gynaecology, Government Raja Mirasudhar Hospital, Thanjavur medical college over a period of 18 months A random selection of 400 antenatal mothers with Non severe preeclampsia was made and were followed up serially every 15 days and outcome was analyzed. Results: There were increase in platelet indices in 213 (94.7%) among 225 patients who turned out to be severe preclampsia which is in agreement with the other studies. Even before the fall in platelet counts, platelet indices such as MPV, PDW are altered which is statistically significant. The platelet indices showed a gradual increase in non severe preeclampsia patients who turned out to be severe pre eclampsia and were statistically significant. Among 400 patients, 225 patients turned into severe preeclampsia, among which 213 (94.7%) had abnormal platelet indices and 12 (5.3%) had normal platelet indices. Conclusion: In our study the platelet indices found to be increased much earlier before the diagnosis of severe preeclampsia emphasizing their utility in prediction, early diagnosis of severe preeclampsia and risk stratification for optimum feto maternal outcome in preeclampsia women. Provision of quality antenatal health care services, increasing patient awareness about warning symptoms, investigations, timely delivery and intensive care monitoring in the intrapartum and postpartum period have the potential to improve maternal and perinatal outcome.
Keywords: Platelet Distribution, Eclampsia
Edition: Volume 11 Issue 12, December 2022,
Pages: 636 - 641