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Research Paper | Medicine | Indonesia | Volume 11 Issue 12, December 2022
The Correlation of PAI-1 level with Regular Blood Transfusion in Children with Thalasemia Beta Mayor at H. Adam Malik Hospital, Medan
Sutiansi | Bidasari Lubis | Adi Koesoema Aman [4]
Abstract: Background: Beta Thalassemia is a congenital hemoglobin disorder due to a genetic mutation that causes decreases or absent of beta globin chain synthesis. Patients with thalassemia need regular blood transfusions and iron chelating agent throughout their lives. Plasminogen Activator Inhibitor-1 (PAI-1) is a serine protease inhibitor that serves as the primary inhibitor of tissue Plasminogen Activator (tPA) and urokinase Plasminogen Activator (uPA). Increased PAI-1 is a risk factor for thrombosis and atherosclerosis. Methods: This research is an observational study with cross sectional data collection method. This study took blood samples of 32 pediatric patients with beta thalassemia mayor who regularly transfused at the HAM Hospital. PAI-1 is only checked once before the patient has a blood transfusion. The research was conducted after obtaining ethical approval and informed consent. Result and Discussion: 19 boys (64.7%) and 12 girls (35.3%) with the youngest age 1 year and oldest 18 years old. Using spearman correlation tests showed that there is a significant correlation between the length of transfusion with PAI-1 (p = 0.001) with correlation value (r) 0.546. Using spearman correlation tests it was also found that there was a significant correlation between total transfusions with PAI-1 (p = 0.004) with correlation value (r) obtained was 0.500. These findings indicate that the longer the child's subject transfused, it will be followed by increasing levels of PAI-1. Conclusion and Suggestion: PAI-1 levels increase along with the increasing blood transfusions frequency in pediatric patients with Thalassemia. More research is needed to determine the pathogenesis of thrombosis and aterosclerosis in pediatric patients with thalassemia beta major who regularly blood transfusions.
Keywords: Beta Thalassemia Major, Regular Blood Transfusion, PAI-1
Edition: Volume 11 Issue 12, December 2022,
Pages: 218 - 220