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Review Papers | Anaesthesiology | India | Volume 11 Issue 11, November 2022

Comparison of effects of Dexmedetomidine and Clonidine as Adjuvants to Bupivacaine in Ultrasound Guided Supraclavicular Brachial Plexus Block

Dr. Prajwal Patel | Dr. Sangamesh | Dr. Rashmi Ashok Balagattii

Abstract: Background: Dexmedetomidine in comparison to Clonidine provides a longer duration of sensory and motor blockade as well as post-operative analgesia when used as an adjuvant to Bupivacaine in Supraclavicular Brachial plexus block. Methods: 50 patients of ASA1 and ASA2 physical status, aged between 18 to 70 years scheduled to undergo elective upper limb surgical procedures were randomly allocated into two groups of twenty five each. Group A received 0.5% Bupivacaine 20ML + 1mcg/kg Dexmedetomidine and group B received 0.5% Bupivacaine 20ML + 1mcg/kg Clonidine. The patients were monitored for intraoperative hemodynamics. Patients were assessed for the duration of sensory and motor blockade. Results: Onset of sensory blockade was found to be faster in Group A than in Group B, while onset of motor blockade occurred faster in Group B than in Group A, but the difference was not statistically significant (P>0.05). Duration of sensory block was 220.12 ?50.3 min in Group B as compared with 410.34? 60.12 min in Group A. Duration of sensory block was significantly longer in Group A as compared to Group B (P<0.01). The duration of motor block was 280.1? 20.12 min in Group B as compared with 460.4? 50.56 min in Group A. Duration of motor block was also significantly longer in Group A as compared to Group B (P<0.01). Duration of analgesia was significantly increased in Group A (452.7 ?64.23 min) as compared with Group B (270.4? 56.7 min(P<0.01). Conclusion: Dexmedetomidine and Clonidine can be used safely in combination with local anaesthetic in peripheral nerve blocks. However, Dexmedetomidine in comparison to Clonidine provides a longer duration of sensory and motor blockade as well as post-operative analgesia when used as an adjuvant to Bupivacaine in Supraclavicular Brachial plexus block.

Keywords: Bupivacaine, Dexmedetomidine, Clonidine, Supraclavicular Brachial plexus Block, Ultrasound Guidance

Edition: Volume 11 Issue 11, November 2022,

Pages: 1469 - 1470