Thyroid Function as Surrogate Marker of Advancing HIV Infection and its Correlation with CD4 Count
International Journal of Science and Research (IJSR)

International Journal of Science and Research (IJSR)
Call for Papers | Fully Refereed | Open Access | Double Blind Peer Reviewed

ISSN: 2319-7064


Downloads: 3 | Views: 325 | Weekly Hits: ⮙1 | Monthly Hits: ⮙1

Case Studies | Medicine | India | Volume 10 Issue 6, June 2021 | Popularity: 5.3 / 10


     

Thyroid Function as Surrogate Marker of Advancing HIV Infection and its Correlation with CD4 Count

Manoj Mathur, Poonam Gupta, A. K. Chaurasia, Gyan Prakash, Chandan Tripathi


Abstract: Objective: In this study we evaluated thyroid function tests in patients infected with human immunodeficiency virus (HIV) infection at various stages of the illness and correlation of thyroid function tests with CD4 count in patient infected with human immunodeficiency virus (HIV). Methods: This study was done in total 100 HIV positive patients. Correlation between CD4 count and serum Free.T3, FreeT4 and serum TSH was studied. Then correlation between CD4 count and serum Free.T3, FreeT4 and serum TSH was studied in both group A and B separately.Pearson correlation coefficient/Spearman rank correlation coefficient was used to assess the association of various quantitative parameters. A p value of <0.05 was considered statistically significant. Results: The study depicts that there was a strong negative correlation between CD4 count (cu.mm) and STSH (uIU/ml) value and this correlation was statistically significant (rho = -0.74, p = <0.001). In Group B the mean S.Free T3 is about 2.81 ? 0.58, the mean S.Free T4 is about 0.85 ? 0.18. The mean STSH is about 2.57 ? 1.51 and and the mean CD4 is about 395.62 ? 103.76. The study showed that there was a moderate positive correlation between CD4 Count (/cu.mm) and S.Free T3 (pg/mL) this correlation was statistically significant (rho = 0.35, p = 0.014 and ). There was a weak positive correlation between CD4 Count (cu.mm) and S.Free T4 (ng/mL), and this correlation was statistically significant (rho = 0.28, p= 0.048). There was a moderate negative correlation between CD4 Count (/cu.mm) and S.TSH (uIU/mL), and this correlation was statistically significant (rho = -0.35, p = 0.014). The study showed that thyroid dysfunction is more frequent in advanced stage (cdc stage- 3) as compared to early stage (stage 1, 2) and there is hypothyroid like stage that occurs in patients with HIV infection. Conclusion: The results showed that thyroid dysfunction is more frequent in female HIV positive patients as compared to male patients. The results also showed that thyroid dysfunction is more frequent in advanced stage (cdc stage 3) as compared to early stage(stage 0,1,2) and there is hypothyroid like stage that occurs in patients with HIV infection. From the findings of our study we can conclude that thyroid function test can be used as a surrogate marker of advancing HIV infection.


Keywords: Thyroid Function, Surrogate Marker, HIV, CD4


Edition: Volume 10 Issue 6, June 2021


Pages: 461 - 466


DOI: https://www.doi.org/10.21275/MR21605124907



Make Sure to Disable the Pop-Up Blocker of Web Browser


Text copied to Clipboard!
Manoj Mathur, Poonam Gupta, A. K. Chaurasia, Gyan Prakash, Chandan Tripathi, "Thyroid Function as Surrogate Marker of Advancing HIV Infection and its Correlation with CD4 Count", International Journal of Science and Research (IJSR), Volume 10 Issue 6, June 2021, pp. 461-466, https://www.ijsr.net/getabstract.php?paperid=MR21605124907, DOI: https://www.doi.org/10.21275/MR21605124907

Similar Articles

Downloads: 0

Research Paper, Medicine, Indonesia, Volume 11 Issue 1, January 2022

Pages: 1553 - 1555

Differences of Homocysteine Levels in HIV Patients with CD4<200 Cells/?L and CD4>200 Cells/?L

Sinulingga RJ, Loesnihari R, Kembaren T

Share this Article

Downloads: 1 | Weekly Hits: ⮙1 | Monthly Hits: ⮙1

Review Papers, Medicine, Albania, Volume 11 Issue 9, September 2022

Pages: 552 - 554

Lymph Node Pathology in Infectious Diseases

Shkelqim Kurti, Ergys Ramosaco

Share this Article

Downloads: 1 | Weekly Hits: ⮙1 | Monthly Hits: ⮙1

Research Paper, Medicine, India, Volume 13 Issue 8, August 2024

Pages: 1603 - 1610

A Study of C. N. S. Manifestations of 30 HIV Positive Patients

Dr. Maulik Makani, Dr. Bhavik Prajapati, Dr. H. K. Bhavsar, Dr. Sachin Patel, Dr. Urvashi Patel, Dr. Paras Desai, Dr. Prashant Ramnani

Share this Article

Downloads: 1 | Weekly Hits: ⮙1 | Monthly Hits: ⮙1

Case Studies, Medicine, United States of America, Volume 13 Issue 11, November 2024

Pages: 523 - 524

Case Study: A New Treatment for HPV Related Anal Neoplasia

Amelia Kahn, Robin H. Miller

Share this Article

Downloads: 1 | Weekly Hits: ⮙1 | Monthly Hits: ⮙1

Research Paper, Medicine, India, Volume 13 Issue 12, December 2024

Pages: 954 - 957

Thyroid Profile in Liver Cirrhosis Patients - Correlation with Disease Severity and Recommendations for Clinical Practice: A Cross - Sectional Observational Study

Dr. Ayush Lal, Dr. Pranay Swarnkar, Dr. Abhishek Das

Share this Article
Top