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Research Paper | Microbiology | India | Volume 12 Issue 12, December 2023
Antifungal Properties of Graphene Silver Nanocomposites against Candida Sp.
Abstract: The irrational use of antibiotics has made the disease causing microbes resistant to a majority of the antibiotics. This might be because of excessive use of antibiotics or because administration of sub ? lethal doses. This development of antimicrobial resistance (AMR) has become a matter of concern as its occurrence is increasing worldwide. The disease causing microbes are continuously developing new ways to survive in the presence of antimicrobial agents. They adapt to every new antibiotic that is employed for killing them. This has caused an increase in medical complications. Researchers and clinicians have been facing issues due to AMR. So, the discovery of new antimicrobial agents is needed in order to kill resistant cells and to prevent the progression of AMR. Various nanoparticle conjugates have been studied for their use as agents to combat antimicrobial resistance. These compounds can be used in places where antimicrobial materials are required. These nanoparticle composites have applications in various fields, for example ? nanofillers in polymers, cancer therapeutic drugs, killing various gram positive bacteria, gram negative bacteria and clinically significant fungi, Candida albicans. Candida albicans is an opportunistic pathogenic yeast. It is commonly found in the human gut microflora. It is detected in the gastrointestinal tract and mouth in 40?60% of healthy adults. In immunocompromised patients, it causes oropharyngeal or thrush candidiasis. Use of silver ? graphene nanocomposites has been found to show decrease in its growth. This decrease depends on exposure time and concentration of nanoparticles along with which they are incubated. This is studied in order to find the minimum inhibitory concentration of the said nanoconjugates for the particular microorganisms.
Keywords: Antimicrobial resistance, Nanoparticles, Nanoconjugates, Graphene, Nanofillers, Nanocomposites
Edition: Volume 12 Issue 12, December 2023,
Pages: 249 - 254