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Case Studies | Pathology | India | Volume 8 Issue 8, August 2019
Primary CNS Lymphoma: An Institutional Study
Abstract: Introduction: Primary central nervous system lymphoma (PCNSL) is a rare group of extra nodal non-Hodgkin’s lymphomas. It accounts for 2.4-3 % of all brain tumours. Aim & Objectives: To study the clinicopathological & immunohistochemistry profile of patients with PCNSL presented between the years 2010 to 2019 in a tertiary care centre. Materials and Methods: This was a retrospective study. Clinical data were obtained from the hospital clinical case records. All the histopathologically proven cases of PCNSL involving the cerebral parenchyma were considered. All cases were studied in H & E then subjected to immunohistochemistry for LCA, CD20, CD3, GFAP and MIB1. Possibility of secondary involvement by a systemic lymphoma was excluded in every case. Statistical analysis was done by chi square test. Results: There were a total of 41 cases with median age of presentation being 52 years and with a male to female ratio1.15: 1. Headache was the most common presenting complaint. All patients were immunocompetent. Frontal lobe was the most common site of involvement. Diffuse large B cell lymphoma (DLBCL) was the histological pattern in all cases. Conclusion: All the patients were immunocompetent, association of PCNSL cases with HIV or acquired immunodeficiency syndrome was not found in our study. DLBCL constituted the majority of PCNSLs.
Keywords: Primary central nervous system lymphoma, diffuse large B-cell lymphoma, immunophenotyping
Edition: Volume 8 Issue 8, August 2019,
Pages: 1000 - 1003