Downloads: 124 | Views: 257
Research Paper | Medical Science | India | Volume 9 Issue 1, January 2020 | Popularity: 6.7 / 10
Analgesic Efficacy of Dexmedetomidine Versus Fentanyl as an Adjunct to Thoracic Epidural in Patients Undergoing upper Abdominal Surgery: A Prospective Randomized Controlled Trial
Dr. K. Gopa Naik, Dr. A. Vishnu Vardhan
Abstract: Background: This prospective, randomised, double-blind study was designed to assess the analgesic efficacy of dexmedetomidine as compared with fentanyl as an adjunct to local anaesthetic in thoracic epidural for upper abdominal surgeries. Methods: 40 adult patients of American Society of Anaesthesiologists grade III undergoing upper abdominal surgery were randomly allocated into two groups to receive 50 g fentanyl or 50 g dexmedetomidine as an adjunct to 10 ml 0.125 % bupivacaine via thoracic epidural. Anaesthesia was induced with morphine, propofol and vecuronium and maintained by isoflurane with 60 % nitrous oxide in oxygen. In the postoperative period patient-controlled analgesic pumps were used to deliver similar types of mixtures via the epidural catheter. Patients were evaluated for rescue analgesic requirements, haemodynamic stability, postoperative pain, sedation and any adverse events. Results: The groups were comparable regarding intraoperative analgesic requirements, recovery times and postoperative pain scores. The total consumption of rescue analgesia was significantly less in the dexmedetomidine group as compared with the fentanyl group (p = 0.046). Two patients in the fentanyl group had vomiting and one had pruritus. None of the patients had bradycardia, hypotension, excessive sedation or respiratory depression. Patients receiving epidural dexmedetomidine were more satisfied with the technique than those receiving fentanyl (p < 0.001). Conclusion: It was concluded that the addition of dexmedetomidine with 0.125 % bupivacaine in thoracic epidural provides effective perioperative analgesia with greater patient satisfaction compared with fentanyl.
Keywords: adjuvants, dexmedetomidine, fentanyl, postoperative pain, thoracic epidural
Edition: Volume 9 Issue 1, January 2020
Pages: 1055 - 1060
Make Sure to Disable the Pop-Up Blocker of Web Browser
Similar Articles
Downloads: 4 | Weekly Hits: ⮙1 | Monthly Hits: ⮙1
Research Paper, Medical Science, India, Volume 11 Issue 1, January 2022
Pages: 155 - 174Efficacy of Ultrasound-Guided Continuous Transversus Abdominis Plane Block versus Continuous Epidural Analgesia in Postoperative Pain Management Following Abdominal Surgery
Dr. Gayathri G., Dr. Chitra V. R., Dr. Sandhya M. S.
Downloads: 38
Review Papers, Medical Science, Bulgaria, Volume 10 Issue 2, February 2021
Pages: 888 - 891Pharmacogenetic Aspects of Anesthesia and Postoperative Anesthetization
Kameliya Tsvetanova
Downloads: 58
Research Paper, Medical Science, India, Volume 9 Issue 11, November 2020
Pages: 1542 - 1544Comparison of Clonidine & Dexamethasone as Additive to Bupivacaine in Fascia Iliaca Compartment Block for Postoperative Analgesia in Patients Undergoing Lower Limb Orthopedic Surgeries
Dr Mahendra Kumar Gocher, Dr Suresh Pandey, Dr S. P. Chittora
Downloads: 102 | Weekly Hits: ⮙1 | Monthly Hits: ⮙1
Research Paper, Medical Science, India, Volume 10 Issue 1, January 2021
Pages: 140 - 142Comparison of Magnesium Sulphate 100mg and Fentanyl 25?g as Adjuvants to Intrathecal Hyperbaric Bupivacaine 0.5% for Infraumbilical Surgeries
Dr. C. P. Huda, Dr. S.P. Chittora, Dr. Rakesh Choudhary
Downloads: 111
Research Paper, Medical Science, India, Volume 8 Issue 12, December 2019
Pages: 984 - 987Epidural Labour Analgesia What's New: Comparison of 0.125% Ropivacaine-Dexmedetomidine versus 0.125% Levobupivacaine-dexmedetomidine
Satinder Kaur, Meena Singh, Arin Choudhury, Pramod Kumar, Namita Misra, Manjit Kaur Mohi