Downloads: 108 | Views: 290 | Weekly Hits: ⮙2 | Monthly Hits: ⮙2
Research Paper | Pharmacology Science | India | Volume 8 Issue 12, December 2019 | Popularity: 7.3 / 10
Evaluation of Anti Inflammatory Activity of Benazepril in Albino Rats
Meenambal.S, Israel Raja Johnley.I
Abstract: EVALUATION OF ANTI INFLAMMATORY ACTIVITY OF BENAZEPRIL IN ALBINO RATS. MEENAMBAL. S1, *ISRAEL RAJA JOHNLEY. I 1. Assistant Professor of Pharmacology, Government Thoothukudi Medical College, Thoothukudi * Assistant Professor of Pharmacology, Government Thoothukudi Medical College, Thoothukudi INTRODUCTION: Inflammation is a component of the biological response of the body to harmful stimuli. Treating inflammation with the (NSAIDs) leads to adverse effects like gastric discomfort, cardiovascular and renal effects. Indomethacin is a NSAID and its mechanism of action is by inhibiting cyclooxygenase nonselectively. Benazepril is an ACE inhibitor and it inhibits angiotensin II molecule formation. Evidence shows, there is an alteration in angiotensin II molecule is implied in the anti inflammatory effect of benazepril and it is found to be lack of the side effects of NSAIDs. Benazepril exerts its anti inflammatory property by acting on intracellular ROS (reactive oxygen species) production in rats with LV hypertrophy by the down regulation of both NF-B and TGF – signaling pathways. Hence, it suggests that benazepril has an anti inflammatory effect. METHODOLOGY: 1 % Carrageenan induced paw edema in rats. RESULTS: Paw volume of control group increased from baseline ( 0.95+ 0.29) to the third hour (3.2+ 0.43). The standard group had a volume of 0.83+0.25 at baseline, and 1.4+ 0.20 at third hour. Similarly, test groups III, IV, V had a paw volume of 0.91+0.26, 0.87+0.26, 0.79+0.33 at baseline and 2.04+ 0.36, 1.8 +0.26, 1.6+ 0.33 at third hour respectively. CONCLUSION: Benazepril exerts its anti inflammatory property by down regulating both NF-B and TGF - signaling pathways and NO-cGMP pathways.
Keywords: Benazepril, Indomethacin, Carrageenan, Paw edema, Rats
Edition: Volume 8 Issue 12, December 2019
Pages: 1481 - 1485
Make Sure to Disable the Pop-Up Blocker of Web Browser
Similar Articles
Downloads: 142
Research Paper, Pharmacology Science, Indonesia, Volume 7 Issue 11, November 2018
Pages: 1683 - 1688Effectiveness of Sambote Extract on Decreasing Blood Glucose Levels of Male White Rats (Rattus norvegicus) Induced with Sucrose
Dingse Pandiangan, Nelson Nainggolan, Febby Kandou, Edwin de Queljoe
Downloads: 0
Research Paper, Pharmacology Science, India, Volume 11 Issue 5, May 2022
Pages: 99 - 107Anti Pyretic Activity of Linga Mathirai (Mercuric Sulphide Preparation) in Experimental Animals
K. Balagurusamy, S. Balamurugan, S. Semalatha
Downloads: 57
Research Paper, Pharmacology Science, Ivory Coast, Volume 7 Issue 12, December 2018
Pages: 1172 - 11174In Vivo Antitussive Activity of Chrysophyllum welwitschii against Ammonia Liquor-Induced Cough in Rats
Agnero S. M., Pakora G. A., Yeo Dodehe, N'Guessan J. D., Djaman A. J.
Downloads: 98
Research Paper, Pharmacology Science, India, Volume 4 Issue 4, April 2015
Pages: 2002 - 2008Effect of Scoparia dulcis (Linn.) and Aerva lanata (Linn.) Whole Plant and Fruit Part Extracts on Ethylene Glycol Induced Urolithiasis in Male Albino Rats
P. Pandi Lakshmi, Dr. C. D. Lethi, Dr. P. Kokilavani
Downloads: 100
Research Paper, Pharmacology Science, Egypt, Volume 4 Issue 3, March 2015
Pages: 1725 - 1732Effects of the Extracts of Olive and Morus Alba Leaves on Experimentally STZ Induced Diabetes in Male Rats
Omar S. I. Al-Janabi, Amer M. S., Khayri M. H.