To Study the Usefulness of Cartridge Based Nuclear Acid Amplification Test [CBNAAT] in Bronchoalveolar Samples in the Diagnosis of Sputum Negative Patients with Presumptive Pulmonary Tuberculosis
Abstract: Background: About 40‑60 % of patients with presumptive PTB may fail to produce sputum, or when it is available, AFB/ CBNAAT may be negative on repeated smear examination. These patients can be diagnosed by flexible fiberoptic bronchoscopy. Aims- This study was carried out to know the usefulness of bronchoscopy in sputum negative suspected pulmonary tuberculosis patients. Material and method-We identified 68 consecutive cases of suspected pulmonary TB between Nov 2016 and july 2017, who had negative results on sputum smears examination by fluorescent microscopy/ZN staining on at least 2 samples or CBNAAT and did fibre optic bronchoscopy and sent bronchial aspirate for CBNAAT and AFB staining. Result- Males constituted majority of our study population. The most common age group involved in the study was less than 30 years (35.2 %). Cough was the most common symptom reported by 45 patients (66.1 %). The past history of PTB was present 13 patients (19.1 %).27.9 % of study population had consolidation on CXR. Out of 68 clinically suspected sputum negative-PTB patients, 32 patients (47 %) were finally diagnosed as having microbiologically confirmed PTB. CONCLUSION- CBNAAT done on bronchial aspirate can be an important adjunct to bacteriological confirmation of suspected cases who were otherwise sputum negative or not expectorating adequate sputum.
Keywords: CBNAAT, BRONCHOSCOPY, TUBERCULOSIS
How to Cite?: R. K. Panda, Devi Jyoti Dash, "To Study the Usefulness of Cartridge Based Nuclear Acid Amplification Test [CBNAAT] in Bronchoalveolar Samples in the Diagnosis of Sputum Negative Patients with Presumptive Pulmonary Tuberculosis", Volume 9 Issue 2, February 2020, International Journal of Science and Research (IJSR), Pages: 1105-1107, https://www.ijsr.net/getabstract.php?paperid=ART20203226, DOI: https://dx.doi.org/10.21275/ART20203226