Synthesis and in vitro Antibacterial Activity of Novel Substituted N-1, 3-Benzoxazol-2yl Benzene Sulfonamides
International Journal of Science and Research (IJSR)

International Journal of Science and Research (IJSR)
Call for Papers | Fully Refereed | Open Access | Double Blind Peer Reviewed

ISSN: 2319-7064


Downloads: 120 | Views: 321 | Weekly Hits: ⮙1 | Monthly Hits: ⮙1

Research Paper | Chemistry | India | Volume 7 Issue 12, December 2018 | Popularity: 6.5 / 10


     

Synthesis and in vitro Antibacterial Activity of Novel Substituted N-1, 3-Benzoxazol-2yl Benzene Sulfonamides

Gajanan Shanbhag, H. M. Vagdevi


Abstract: From many centuries human beings have been exposed to pathogens. In current modern medicine microbial infections are a major growing problem in which only a few antimicrobial agents are used in medical practice. Though several antimicrobial agents are currently available, there is a critical need for the development of new and specific antimicrobial agents. Amongst them benzoxazole derivatives constitute much importance in medicinal field due to their broad range of biological activity. Two novel N-1, 3-Benzoxazol-2yl benzene sulfonamides have been synthesized by cyclizing four different amino alcohols with Cyanogen bromide to get 1, 3-benzoxazol-2-amine which upon treating with substituted phenyl sulfonyl chlorides gave novel N-1, 3-Benzoxazol-2yl benzene sulfonamides. After structural confirmation, the title compounds were screened for their antimicrobial and anti oxidant activity. The obtained compounds were tested for antimicrobial activity against Staphylococcus aureus and Escherichia coli at 30ppm and 300ppm and subjected the same compound for molecular docking studies with respect to antimicrobial activity. Both the compounds 3a (N- (7-bromo-1, 3-benzoxazol-2yl) -4-methylbenzene-1-sulfonamide) and 3b (4- bromo-N- (7-methyl-1, 3-benzoxazol-2-yl) benzene-1-sulfonamide) showed pronounced antimicrobial activity.


Keywords: antibacterial activity, sulfonamides, benzoxazole


Edition: Volume 7 Issue 12, December 2018


Pages: 715 - 717



Make Sure to Disable the Pop-Up Blocker of Web Browser


Text copied to Clipboard!
Gajanan Shanbhag, H. M. Vagdevi, "Synthesis and in vitro Antibacterial Activity of Novel Substituted N-1, 3-Benzoxazol-2yl Benzene Sulfonamides", International Journal of Science and Research (IJSR), Volume 7 Issue 12, December 2018, pp. 715-717, https://www.ijsr.net/getabstract.php?paperid=ART20193634, DOI: https://www.doi.org/10.21275/ART20193634

Similar Articles

Downloads: 0

Research Paper, Chemistry, India, Volume 11 Issue 2, February 2022

Pages: 957 - 959

Evaluation of Antimicrobial Activity of Some Thia-1, 3, 4-Oxadiazolophanes

Varsha V. Thorat

Share this Article

Downloads: 1 | Weekly Hits: ⮙1 | Monthly Hits: ⮙1

Research Paper, Chemistry, India, Volume 13 Issue 2, February 2024

Pages: 766 - 769

Synthesis and Characterization of Coordination polymers of Bis-(mercaptoacatamido) - Butanedioane Dihydrazone

A. D. Bansod

Share this Article

Downloads: 1 | Weekly Hits: ⮙1 | Monthly Hits: ⮙1

Doctoral Thesis, Chemistry, India, Volume 14 Issue 1, January 2025

Pages: 315 - 318

Synthesis, Spectral Characterization, Thermal Behavior and Biological Studies of Co(II), Cu(II), Mn(III) and Fe(III) Metal Complexes of Schiff Base Ligand

S. B. Rathod, P. R. Mandlik

Share this Article

Downloads: 2 | Weekly Hits: ⮙2 | Monthly Hits: ⮙2

Research Paper, Chemistry, India, Volume 13 Issue 1, January 2024

Pages: 1088 - 1090

Synthesis of Schiff Base Metal Complexes of 1-(2-hydroxy-5-methylphenyl) Ethan-1-One and Benzohydrazide, Their Characterization and Biological Studies

V. A. Sadafale

Share this Article

Downloads: 4 | Weekly Hits: ⮙1 | Monthly Hits: ⮙1

Research Paper, Chemistry, Iraq, Volume 10 Issue 11, November 2021

Pages: 1017 - 1021

Synthesis, Characterization, Thermal Analysis, and Antibacterial Activity of New Tetradentate Ligands and their Complexes

Basher J. Kadhim, Jasim Alshawi, Tahseen Alslaim

Share this Article
Top