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Review Papers | Pharmaceutical Science | India | Volume 7 Issue 12, December 2018

Solubility Enhancement Techniques of Poorly Water Soluble Drug

Sathish Ananthan | Karri Vvs Narayana Reddy

Abstract: The poorly aqueous solubility of BCS class II drug represent a major challenge for oral dosage form development. Poorly aqueous solubility for new chemical entities present various challenges in development of effective drug delivery system for various delivery routes. Chemical Entities has dramatically increasing solubility and permeability. Solubilization technology having to increasing dissolution and dissolved drug in level on to acheieve the extent or oral absorption. Term solid dispersion refer to group of solid product consisting least two different component generally hydrophilic drug and hydrophobic drug. Solid dispersion in water soluble carrier engrossed in the increase dissolution rate and bioavability in hydrophobic drug. For enhancement of solubility dissolution rate poorly water soluble drug, according to (chiou and Rielman 1971) pharmaceutical solid dispersion is the dispersion of one or more active ingredient inert carrier matrix are solid state. Solubility behavior of drug remain one of the exigent aspect in formulation development. Solid dispersion as dosages form has been established superior option for the drug having poorly aqueous solubility. A solubility dispersion generally composed of two component the drug and polymer matrix. An numerous method are existing to prepare the solid dispersion or solubility such as melting method, solvent Evaporation method, fusion method, kneading method, spray drying, co-grinding method, lyphilization method, hot melt extrusion method, melt agglomeration method, supercritical fluid method, etc.

Keywords: poorly water soluble, solubility enhancement, dissolution, spray drying versus freeze drying

Edition: Volume 7 Issue 12, December 2018,

Pages: 553 - 560