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Research Paper | Biochemistry | Volume 7 Issue 8, August 2018 | Pages: 498 - 506 | Venezuela
Role of Phosphatidylinositol-3 and Mitogen-Activated Protein Kinases on Rat Retinal Cells Size and Neurite Outgrowth in the Absence and in the Presence of Taurine
Abstract: This study examined the effect of phosphatidylinositol-3 protein kinase (PI3K), LY 294002 and wortmannin, and of mitogen activated protein kinases (MAPK) inhibitors, PD 98059 and SB 203580, on rat retinal cells size and neurite outgrowth in the absence and in the presence of taurine. Isolated cells were cultured for 5 days in minimal essential medium containing taurine (4 mM) and the inhibitors at different concentrations (2.5, 10, 20, 25 M). Size of ganglion cells was measured and outgrowth was evaluated by the length of the largest neurite (m), in cells
Keywords: retina, taurine, kinases, neurite, outgrowth
How to Cite?: Jeilyn D Vivas, Lisbeth R Cubillan, Lucimey Lima, "Role of Phosphatidylinositol-3 and Mitogen-Activated Protein Kinases on Rat Retinal Cells Size and Neurite Outgrowth in the Absence and in the Presence of Taurine", Volume 7 Issue 8, August 2018, International Journal of Science and Research (IJSR), Pages: 498-506, https://www.ijsr.net/getabstract.php?paperid=ART2019295, DOI: https://dx.doi.org/10.21275/ART2019295