Osteocalcin Level and its Association with Vitamin D Receptor Gene Polymorphisms (TaqI and ApaI) in Iraqi Obese Type 2 Diabetes Mellitus
Abstract: In order to explore the association of serum 25- hydroxy vitamin D concentration and it is gene receptor polymorphisms with Osteocalcin state for Iraqi obese type 2 diabetes mellitus individuals. Genomic DNA was obtained from leucocytes by using a standard salting out process. The polymorphisms had been genotyped by PCR -RFLP technique by using certain primers. ELISA was used to evaluate Insulin and Osteocalcin along with other biochemical parameters concentration. A significant reduction in Osteocalcin concentration within obese type 2 diabetes mellitus Iraqi individuals in comparability with the healthy obese non diabetic control group. The reduction depends on a number of elements, like period of disease and age individuals, aside from that to BMI. Mean serum Osteocalcin proved excellent correlations with intact parathyroid hormone (PTH) (r= 0.471, P
Keywords: Vitamin D receptor, gene polymorphism, Type 2 diabetes mellitus, Osteocalcin
How to Cite?: Reema M. Abed, "Osteocalcin Level and its Association with Vitamin D Receptor Gene Polymorphisms (TaqI and ApaI) in Iraqi Obese Type 2 Diabetes Mellitus", Volume 6 Issue 12, December 2017, International Journal of Science and Research (IJSR), Pages: 1599-1604, https://www.ijsr.net/getabstract.php?paperid=ART20179146, DOI: https://dx.doi.org/10.21275/ART20179146