Pathogenic Activity of Methicillin-Resistant Staphylococcus aureus Strains Isolated from Colorectal Cancer Patients

Shorena Khetsuriani, Khatuna Pochkhua, Maia Zarnadze

Abstract: There were studied pathogenic activity of methicillin-resistant Staphylococcus aureus (MRSA) strains isolated from colorectal cancer patients and were compared to non-MRSA strains isolated from patients with intestinal dysbiosis. The aim of study was to determine changes of biological properties of this important bacterium depend on the severity of disease. Study revealed that MRSA strains are widespread in patients with colorectal cancer. MRSA strains revealed higher pathogenic activity than non-MRSA strains. Some determinants of pathogenicity (urease, lecithinase production, hemolysis, proteolysis), also carbohydrate and mannitol fermentations in aerobic and anaerobic conditions are characterized with high activity in MRSA strains in comparison of non-MRSA strains. Coagulase- and catalase-positive were all strains from both groups.

Keywords: MRSA, colorectal cancer, S aureus, pathogenic factors, enzymes, carbohydrate fermentation