A Retrospective Study on Different Treatment Modalities of Hepatocellular Carcinoma in Assiut Governorate

Nada Hassan Salah M.B.B.CH, Samir Shehata Mohammed MD, Hoda Hassan Eisa MD, Ola Nabih Abdel Fattah MD

Abstract: Introduction the management of HCC in assiut governorate is affected by many factors that would affect the choice and effectiveness of treatment. Aim of the work to identify the different lines of management of HCC and factors associated with them. Methods retrospective study that included 146 patients with primary hepatocellular carcinoma (HCC), admitted to Assiut university hospital and El Rajhi hospital during the period from January 2012 to December 2014 Results the main lines of HCC management included 5 lines surgery (resection/transplantation), local ablation, TACE, chemotherapy and Best supportive care. The most significant factors that affected treatment choice and results were Child pugh score, primary tumor size and multiplicity. Conclusion The best cure rate was found in small or single lesions or child pugh score A managed with surgical resection. TACE was the most widely used modality. lesions more than 5 cm or multiple lesions or child pugh score B or C were associated with chemotherapy and best supportive care.

Keywords: hepatocellular carcinoma, epidemiology, upper Egypt, treatment modalities