Inducible Clindamycin Resistance in Staphylococcus aureus Isolates in a Community Setting
International Journal of Science and Research (IJSR)

International Journal of Science and Research (IJSR)
Call for Papers | Fully Refereed | Open Access | Double Blind Peer Reviewed

ISSN: 2319-7064


Downloads: 120 | Views: 312

Research Paper | Medical Microbiology | Sri Lanka | Volume 6 Issue 6, June 2017 | Popularity: 6.7 / 10


     

Inducible Clindamycin Resistance in Staphylococcus aureus Isolates in a Community Setting

Harshi Abeygoonawardena, Mahendra Gunewardane


Abstract: Background The resistance to antimicrobial agents among Staphylococci is an increasing problem. This has led to renewed interest in the usage of Macrolide-Lincosamide-Streptogramin B (MLSB) antibiotics to treat Staphylococcus aureus (S. aureus) infections. The resistance to macrolide can be mediated by msr A gene coding for efflux mechanism or via erm gene encoding for enzymes that confer inducible or constitutive resistance to MLSB antibiotics. In vitro routine tests for clindamycin susceptibility may fail to detect inducible clindamycin resistance due to erm genes resulting in treatment failure, thus necessitating the need to detect such resistance by a simple D test on a routine basis. Objective This study was carried out to determine the prevalence of MLSBi resistance in both S. aureus isolates, including Methicillin Resistant Staphylococcus aureus (MRSA) and Methicillin Sensitive Staphylococcus aureus (MSSA). Results Out of the 88 Staphylococcus aureus isolates, 18 (20 %) were MRSA and 70 (80 %) were MSSA.41 (47 %) isolates were erythromycin resistant. These erythromycin resistant isolates, when subjected to D test, 17 isolates showed MS phenotype, 13 showed inducible MLSB phenotype and 11isolates showed constitutive MLSB phenotype. Out of 18 MRSA isolates 08 (44 %) showed Inducible MLSB phenotype and 02 (11 %) showed Constitutive MLSB phenotype, while in 70 methicillin sensitive Staphylococcal isolates 05 (7 %) showed Inducible MLSB phenotype and 09 (13 %) showed Constitutive MLSB phenotype. The percentage of inducible resistance was higher amongst MRSA isolates as compared to MSSA isolates. Conclusions Clindamycin is kept as a reserve drug and is usually advocated in severe MRSA infections depending upon the antimicrobial susceptibility results. This study showed that D test should be used as a mandatory method in routine disc diffusion testing to detect inducible clindamycin resistance in Staphylococci for the optimum treatment of patients.


Keywords: Constitutive clindamycin resistance, D test, Inducible clindamycin resistance, MRSA, Staphylococcus aureus


Edition: Volume 6 Issue 6, June 2017


Pages: 234 - 238



Make Sure to Disable the Pop-Up Blocker of Web Browser


Text copied to Clipboard!
Harshi Abeygoonawardena, Mahendra Gunewardane, "Inducible Clindamycin Resistance in Staphylococcus aureus Isolates in a Community Setting", International Journal of Science and Research (IJSR), Volume 6 Issue 6, June 2017, pp. 234-238, https://www.ijsr.net/getabstract.php?paperid=ART20174183, DOI: https://www.doi.org/10.21275/ART20174183

Similar Articles

Downloads: 0

Analysis Study Research Paper, Medical Microbiology, India, Volume 11 Issue 8, August 2022

Pages: 1411 - 1413

Analysis of Different Tests for Diagnosis of Pulmonary Tuberculosis

Anita Kulkarni, Dr. Kirti Dubey, Dr. Pallavi Wanjari, Dr. Yagnesh Thakar

Share this Article

Downloads: 1 | Weekly Hits: ⮙1 | Monthly Hits: ⮙1

Research Paper, Medical Microbiology, India, Volume 11 Issue 10, October 2022

Pages: 726 - 728

Isolation of Aerobic Bacteria from Pus Sample and their Antibiotic Sensitivity Pattern in a Tertiary Care Hospital in Western Odisha

Dr. Sneha Sahu, Dr. Yogyata Rani Kumbhar

Share this Article

Downloads: 1 | Weekly Hits: ⮙1 | Monthly Hits: ⮙1

Research Paper, Medical Microbiology, India, Volume 12 Issue 5, May 2023

Pages: 1706 - 1711

A Comparative Study of different Diagnostic Modalities, ZN Stain, Culture and TrueNat for the detection of Pulmonary TB in Sputum Sample and To Study their Co - infection with HIV at a Tertiary Care Hospital

Arpita Kushwaha, Dr. R. Sujatha

Share this Article

Downloads: 1 | Weekly Hits: ⮙1 | Monthly Hits: ⮙1

Analysis Study Research Paper, Medical Microbiology, India, Volume 13 Issue 6, June 2024

Pages: 680 - 683

Microbial Profile of Corneal Scrapping Samples Received in Department of Microbiology in a Tertiary Care Hospital, Himachal Pradesh

Dr. Manvi Sharma, Dr. Dogra Kumari Deeksha, Dr. Rana Aditya, Dr. Sood Anuradha C, Dr. Kaur Isampreet

Share this Article

Downloads: 2 | Weekly Hits: ⮙1 | Monthly Hits: ⮙2

Research Paper, Medical Microbiology, India, Volume 14 Issue 1, January 2025

Pages: 948 - 951

Recent Trends in LSCS Surgical Site Infections and Therapeutic Strategies

Dr. Winston Rose Cr, Dr. Deepa S, Dr. Amrutha Kumari B

Share this Article
Top