International Journal of Science and Research (IJSR)

International Journal of Science and Research (IJSR)
Call for Papers | Fully Refereed | Open Access | Double Blind Peer Reviewed

ISSN: 2319-7064

Downloads: 129 | Views: 178

Review Papers | Pathology | India | Volume 6 Issue 6, June 2017

Impaired Beta Amyloid Synthesis in Alzheimer's Disease

Davinaa Jayasilan [5]

Abstract: Alzheimers disease (AD) is neurodegenerative disease. It is clinically categorized by progressive deterioration of memory, and pathologically by histopathological changes including extracellular deposits of amyloid-beta (A) peptides forming senile plaques (SP) and the intracellular neurofibrillary tangles (NFT) of hyperphosphorylated tau in the brain. The cause of the disease is still uncertain. However, there are various hypotheses suggesting the pathogenesis of this disease and The Amyloid Hypothesis which postulates that the deposition of beta-amyloid causing AD is widely accepted. The impaired synthesis of the (A) has significant implications on the pathogenesis of the disease.

Keywords: alzheimers, beta amyloid

Edition: Volume 6 Issue 6, June 2017,

Pages: 109 - 110

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