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Review Papers | Dental Science | India | Volume 6 Issue 5, May 2017
Survival of Red Blood Cell in Hereditary Spherocytosis
Abstract: The in vivo survival of hereditary spherocytes has been investigated with the 51Cr red cell survival technique. Spherocytes invariably showed a shorter survival in a normal recipient than in the donor's own circulation. Moreover transfusion of spherocytes from a mother to her son, both with hereditary spherocytosis, showed that foreign spherocytes have a shorter survival than the self spherocytes of the recipient. These findings are attributed to splenic reticuloendothelial blockade, specific towards hereditary spherocytes in the patient's own circulation. There was no correlation between the Na' influx and the hemolytic tendency of hereditary spherocytes when the latter was measured by the survival t1/2 in compatible normal recipients. However osmotic fragility influenced cell survival since cells with high fragility were rapidly sequestered in the normal spleen. It is suggested that both cell shape and a selective reticuloendothelial blockade in the spleen are important factors in determining the severity of hemolysis in the individual patient.
Keywords: Hereditary spherocytosis, Red blood cell, Survival of red blood cell
Edition: Volume 6 Issue 5, May 2017,
Pages: 38 - 42