Neurodegenerative Disorders Associated with Mercuric Chloride Toxicity in Mice and the Role of Some Antioxidant

Mahmoud Abdel-Zaher, Mokhtar M. M. Taha, Hanaa G. Ahmed

Abstract: Mercuric chloride toxicity experimentally induced in mice were associated with chronic neuropathology in brain including ischemic neuronal injury, spongiosis, liqufactive necrosis, perivascular and precellular edema, congestion and hyalinization of chroid plexus of lateral and fourth ventricles of the brain. These changes were observed in cerebral cortex, hypothalamus and cerebellum. The experimental animal showing clinical signs related to neuropathological changes as impared response to noise, loss of perfect movement and sleeping altitude. Co-adminstration of garlic and ginger oil together with mercuric chloride greatly inhept the above mentioned changes and result an improvement and recovery, so in area with suspected mercuric chloride pollution we advised that garlic and ginger must be a constant component of food.

Keywords: mercuric, toxicity, mice, brain