Adoption of Oral Disease-Modifying Treatments for Multiple Sclerosis in Europe and the United States between 2012 and 2015
International Journal of Science and Research (IJSR)

International Journal of Science and Research (IJSR)
Call for Papers | Fully Refereed | Open Access | Double Blind Peer Reviewed

ISSN: 2319-7064


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Research Paper | Medicine Science | United States of America | Volume 5 Issue 8, August 2016 | Popularity: 6.5 / 10


     

Adoption of Oral Disease-Modifying Treatments for Multiple Sclerosis in Europe and the United States between 2012 and 2015

Siva Narayanan, Simone Gabriele, Joanna White, Emily Hautamaki


Abstract: A retrospective chart review of multiple sclerosis (MS) patients in EU (UK/France/Germany/Italy/Spain) and the United States (US) was conducted to evaluate adoption of oral disease-modifying treatments (DMTs) for MS, and corresponding patient disease characteristics. In 2012 and 2015 respectively, 3490 (EU2479, US1011) and 3732 (EU2724, US1008) charts were ed. Use of oral DMT increased (EU11.3-35.6 %, US9.2-40.0 %) between 2012-2015 with the largest increase observed in first line therapy, and the percentage citing oral administration or patient decision as reasons for choice of DMT increased over this time period. Among oral DMT users, the proportion with moderate/severe disease severity (EU74.8-45.5 %, US64.4-48.8 %) and mean Expanded Disability Status Scale (EDSS) scores (EU3.6-2.7, US3.2-3.0) decreased between 2012-2015, while remaining stable for non-oral DMT users. Further research is warranted to evaluate the drivers behind the observed trends and impact of individual DMTs on patient outcomes.


Keywords: Multiple sclerosis, disease modifying treatments, oral, disease severity, retrospective chart review


Edition: Volume 5 Issue 8, August 2016


Pages: 163 - 168


DOI: https://www.doi.org/10.21275/ART2016720



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Siva Narayanan, Simone Gabriele, Joanna White, Emily Hautamaki, "Adoption of Oral Disease-Modifying Treatments for Multiple Sclerosis in Europe and the United States between 2012 and 2015", International Journal of Science and Research (IJSR), Volume 5 Issue 8, August 2016, pp. 163-168, https://www.ijsr.net/getabstract.php?paperid=ART2016720, DOI: https://www.doi.org/10.21275/ART2016720

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