Sudan III Azo Dye: Oxidative Stress with Possible Geno and Hepatotoxic Effects in Male Rats
Abstract: Azo compounds were widely used in industry. Although they are not permitted in food, they had been found contaminating different foodstuffs. In the present study, the geno and hepatotoxic effects of Sudan III were estimated with relation to oxidative stress. Rats (n=18) were randomly divided into three groups each of 6. First group were left as control, the remaining two groups, were orally administrated either 125 mg/kg body weight of Sudan III (1/40 LD50), or 250 mg/kg body weight of Sudan III (1/20 LD50) for consecutive 45 days. Rats then sacrificed, blood and tissue samples were harvested. DNA was extracted then fragments were analyzed in the automatic multicapillary electrophoresis, the serum activity of GOT and GPT were measured. Moreover, serum Glu, Alb and TP were evaluated. Lipid profiles were assessed through measuring of Chol, Trig, HDL and LDL. Liver GSH, CAT, SOD and MDA concentrations were evaluated. Our results revealed that, oral administration of Sudan III for 45 days caused serum Glu, GOT and GPT activities to increase significantly (P
Keywords: Sudan III, Genotoxicity, Oxidative stress, Hepatotoxicity
How to Cite?: Samar S. Mohamed, Shereen M. Mahmoud, Rania Abdelrahman Elgawish, Kawther A. Elhady, "Sudan III Azo Dye: Oxidative Stress with Possible Geno and Hepatotoxic Effects in Male Rats", Volume 5 Issue 10, October 2016, International Journal of Science and Research (IJSR), Pages: 1700-1704, https://www.ijsr.net/getabstract.php?paperid=ART20162590, DOI: https://dx.doi.org/10.21275/ART20162590