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Case Studies | Histopathology | India | Volume 5 Issue 10, October 2016
Ovarian Sertoli-Leydig Cell Tumour, A Rare Neoplasm: A Case Report
Dr. Sujata S Giriyan [2] | Dr. Sameera N
Abstract: Sertoli-Leydig cell tumours are uncommon tumours comprising less than 0.5 % of ovarian neoplasms. It is a sex cord stromal tumour. As the name indicates, Sertoli-Leydig cell tumours are composed of a mixture of variable proportions of cells morphologically resembling male Sertoli and Leydig cells. Most tumours are unilateral and confined to ovaries. And they are seen during the second and third decades of life. These tumours are characterized by the presence of testicular structures that produce androgens. Hence, many patients have symptoms of virilisation depending on the quantity of androgen production. Small subsets of them are hyperestrogenic. The second characteristic feature of this tumour is the degree of differentiation of structure in them. Histologically, these are classified (WHO) as well-differentiated, with intermediate differentiation, poorly differentiated, with heterologous components and retiform type. Prognosis depends upon the degree of tumour differentiation (grading) and tumour extent (staging).
Keywords: Sertoli-Leydig cell tumour, sex cord stromal tumour, ovary, androgens, differentiation
Edition: Volume 5 Issue 10, October 2016,
Pages: 200 - 203