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Research Paper | Medicine Science | Ghana | Volume 3 Issue 6, June 2014

Assessment of Free and Total Prostate Specific Antigen Levels among a Cross-Section of Ghanaian Men with Prostate and Liver Diseases

H. Asare-Anane | Osman M. Yunusah | Emmanuel K. Ofori | Francis A. Yeboah

Abstract: The primary site of Prostate Specific Antigen (PSA) metabolism is the liver. PSA is however not cancer specific and high levels can also be found in benign prostate hyperplasia (BPH). Again; diseases or disorders of liver metabolism could contribute to differences in the ratio of free to total PSA levels in serum. The aim of this study was to investigate the effect of liver disease on total and free PSA levels in a cross-section of Ghanaian men. Thirty-six (36) prostate cancer subjects; 28 benign prostate hyperplasia subjects; 23 cirrhosis of the liver subjects and 25 subjects with hepatitis B were age-matched with 131 control subjects. Liver function tests; free and total PSA were measured. Mean free PSA (fPSA) values were highest in cancer of the prostate subjects and least in hepatitis B subjects. Significant associations were observed for fPSA and tPSA values between the control group with CA of the prostate (p

Keywords: Prostate Specific Antigen, Hepatitis, Cirrhosis of liver, Benign Prostate Hyperplasia

Edition: Volume 3 Issue 6, June 2014,

Pages: 2511 - 2514