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Research Paper | Biotechnology | Volume 3 Issue 6, June 2014 | Pages: 2206 - 2212 | India
Mutation Pressure Dictates Codon Usage Pattern in Mitochondrial Atpase8 in Some Mammalian Species
Abstract: Background: Codon usage bias is the phenomenon of unequal use of synonymous codons in a gene; some codons are more preferred than others. However codon usage pattern is different in different genes and organisms and is mainly caused by mutation and selection pressure. Codon usage bias is mostly found in highly expressed genes. Mammals are the highly evolved organisms in animal kingdom. Study of codon usage bias helps in better understanding of molecular biology; genetics and evolution of genes. Methods and Result: We used bioinformatics approach to understand the pattern of codon usage bias of mitochondrial atpase8 gene in ten species of mammals. We have found that GC content varies from 27.5 to 46.4 % with a mean of 37.495.12 and GC content at 3rd codon position varies from 16.2 to 47.8 % with a mean of 34.119.76. ENC values are much higher and range from 42 to 60 with a mean of 54.15.93. A highly positive correlation was found between ENC and GC (r=0.9333; p
Keywords: Codon usage, mutation pressure, mitochondria, mammals
How to Cite?: Arif Uddin, Supriyo Chakraborty, "Mutation Pressure Dictates Codon Usage Pattern in Mitochondrial Atpase8 in Some Mammalian Species", Volume 3 Issue 6, June 2014, International Journal of Science and Research (IJSR), Pages: 2206-2212, https://www.ijsr.net/getabstract.php?paperid=2014665, DOI: https://dx.doi.org/10.21275/2014665