Development and Validation New Analytical Methods of Levofloxacin in IV Infusions by UV-Visible spectrophotometric Methods and Determine Assay; % Purity and Stability in Three Marketed Brands

Swapna.G, Deepika.G

Abstract: The present study was undertaken to develop and validate a simple; accurate; precise; reproducible and cost effective UV-Visible spectrophotometric method for the estimation of levofloxacin in bulk and pharmaceutical formulation in three different Brands of cipla lkem; pdpl throught the experiment the solvent used for uv method was water and the absorption spectra was carried out at 288nm and forvisible method reagent used is 2; 4 DNP in methanol and determination carried out at 510 nm. The concentration range is 2-10g/ml. The method was shown linear in the mentioned concentrations with correlation coefficient of R20.9999. The %purityof levofloxacin is 97.4 %-115.2 %. The percent relative standard deviation (RSD %) of method precision and intermediate prescision is

Keywords: Levofloxacin, uv, visible, Assay, Purity, Stability