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Research Paper | Biology | Nigeria | Volume 5 Issue 9, September 2016
Eosinophilic Responses to the Parasitaemia of Plasmodium Falciparum Treated Malaria In Children, Lake-Alau, North Eastern Nigeria
M. Kokori [4] | J. M. Turaki
Abstract: This study assessed the recovery patterns of children (6-59 months) from malaria using the relationship between eosinophils concentration and parasite densities trends. Two groups where were treated for malaria infections, namely, Artesunate + Sulphadoxine-Pyrimethamine (AT+SP) or Amodiaquine + Sulphadoxine-Pyrimethamine (AQ+SP) in uncomplicated Plasmodium falciparum for 28 days, using the standard therapeutic protocols of the World Health Organization. The results shows a weak association between eosinophil concentrations and parasite densities over segments of the study period of days 0 - 28 using the two combination drugs. The results show r-values of 0.2848 versus 0.1207 for AT+SP versus AQ +SP, respectively. There was higher mean eosinophillic elicitation in AQ+SP (b-values = 0.4137) compared to AT+SP (b-value = 0.2037). The results also shows an eosinophilic reduction with parasite depletion in general but concentration at enrollments were close and marginal for both AT+SP (8.8959 %) and AQ+SP (8.4545 %) patients. The effect of parasitaemia on eosinophils was generally low for both drugs which ranged from 7.12 % for AT+SP to 12.07 % for AQ+SP patients.
Keywords: Eosinophils, Parasitaemia, Plasmodium falciparum, Artesunate, Amodiaquine, Lake-Alau
Edition: Volume 5 Issue 9, September 2016,
Pages: 1787 - 1790