Formulation Development of Oral Liquisolid System of Poorly Water Soluble Drug, Piroxicam, Using Mixed Solvency Concept and their Evaluations

Shruti Jain, Rajesh Kumar Maheshwari

Abstract: The present work are to enhance the drug loading capacity in liquisolid system, increase the flow property due to decrement in required volume of nonvolatile solvent and enhance the solubility of drug in nonvolatile solvent by using mixed solvency concept. Piroxicam was selected as model poorly water soluble drug for exploring the mixed solvency concept to enhance the solubility and hence to enhance the release rate of drug. The proposed formulation is aimed to enhance solubility of piroxicam by employing mixed solvency concept and to develop the fast release capsule of piroxicam by using liquisolid technique.

Keywords: Solubility, piroxicam, liquisolid system, mixed solvency concept, fast dissolution