International Journal of Science and Research (IJSR)

International Journal of Science and Research (IJSR)
Call for Papers | Fully Refereed | Open Access | Double Blind Peer Reviewed

ISSN: 2319-7064




Downloads: 133 | Views: 211

Research Paper | Chemistry | India | Volume 3 Issue 9, September 2014 | Rating: 6.1 / 10


Synthesis, Characterization and Antimicrobial Activities of Some Pyrazoline Derivatives

J. V. Phirke | Y. K. Meshram [2]


Abstract: Some new fused pyrazolines3-methyl-1, 4, 5-triphenyl-1, 3a, 4, 5tetrahydropyrazolo [3-4c]pyrazole, 4 (4-Bromophenyl) 3 methyl -1, 5-diphenyl -1, 3a, 4, 5 tetra hydrophyrozolo [3, 4c] pyrazole, 4 (4-chlorophenyl) 3 methyl -1, 5-diphenyl -1, 3a, 4, 5 tetra hydrophyrozolo [3, 4c] pyrazole 4 (4-Nitrophenyl) 3 methyl -1, 5-diphenyl -1, 3a, 4, 5 tetra hydrophyrozolo [3, 4c] pyrazole, 4 (4-methoxyphenyl) 3 methyl -1, 5-diphenyl -1, 3a, 4, 5 tetra hydrophyrozolo [3, 4c] pyrazole, 4 (4 methyl -2, 6-diphenyl -2, 3, 3a, 6 tetra hydrophyrozolo [3, 4c] pyrazol-3-yl) phenol, pyrazole are prepared by condensation of 1-phenyl-3-methyl-5-pyrazolone with substituted benzaldehyde under microwave irradiation afford chalcones which under cyclization with phenyl hydrazine to afford fused pyrazolines. Synthesized compound confirmed by suitable spectroscopic technique such as 1HNMR. The compounds were screened for their in antibacterial activity against S. aureus E. coli, S. typhi bacteria.


Keywords: Microwave irradiation, Pyrazolines, spectral data, antibacterial activity


Edition: Volume 3 Issue 9, September 2014,


Pages: 1217 - 1219



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