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Research Paper | Medicine Science | India | Volume 3 Issue 12, December 2014

A Pilot Study to Compare Effects of Mannitol with Hypertonic Saline in Combination with HES on Blood Coagulation and Platelet Function during Elective Craniotomy

Vidhu Bhatnagar ^[3]

Abstract: Neurosurgery requires the use of osmotic agents to reduce intracranial pressure which can adversely affect coagulation. Thromboelastography provides early indicator of derangement of coagulation. A prospective, non randomised pilot study was conducted to compare the effect of administration of either mannitol or hypertonic saline and when combined with hydroxy ethyl starch on coagulation and platelet function, as measured by Thromboelastography.22 neurosurgical patients, divided into 2 groups, received 20 % mannitol (n=12) or 3 % hypertonic saline (n = 10) followed by administration of hydroxy ethyl starch (HES). The Thromboelastography parameters were comparable in both the groups at baseline; after administration of the drug and also after HES administration. The results show that combining a single dose of either mannitol or hypertonic saline with hydroxyl ethyl starch does not appear to affect in-vivo coagulation.

Keywords: Mannitol, Saline solution, Hypertonic, Hydroxyethyl starch, Thromboelastography, Coagulation

Edition: Volume 3 Issue 12, December 2014,

Pages: 1115 - 1119

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