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Review Papers | Chemical Sciences | India | Volume 9 Issue 8, August 2020

A Review on Chemometrics in Pharmaceutical Analysis

Bhavana V ^[4] | Srinivasa Rao Y ^[3]

Abstract: Chemometrics is a science which involves the application of statistical and mathematical methods to the analytical data for the collection and extraction of information which is useful for analyzing the results. Chemometrics is an essential tool for multivariate data collection and analysis protocols, calibration, process modelling, pattern recognition and classification, signal correction and compression, and statistical process control. It involves various chemometric techniques like bilinear and multivariate models by using spectroscopic, chromatographic and electrochemical methods which helps in the identification and quantitative analysis of active substances in complex mixtures. This review describes various chemometric methods which is mainly applicable for interpretation of UV/Visible spectra, and also the data obtained by other instrumental methods including near infrared (NIR), attenuated total reflectance Fourier transform infrared (ATR-FTIR), terahertz pulse spectroscopy, fluorescence spectroscopy, electroanalysis, high-performance liquid chromatography (HPLC), and flow-injection analysis for the analysis of drugs in pharmaceutical preparations.

Keywords: Chemometrics, bilinear model, multiway model, spectroscopy, chromatography, pharmaceutical analysis

Edition: Volume 9 Issue 8, August 2020,

Pages: 1008 - 1016

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