Downloads: 103
Research Paper | Biochemistry Science | India | Volume 5 Issue 6, June 2016
Study of Serum High-Sensitivity C-Reactive Protein, Ferritin and Glycated Hemoglobin Levels in Patients with Type 2 Diabetes Mellitus
Dr. Sushma B Jagannatha | Dr. Shrikant Chandrakar
Abstract: Introduction Systemic inflammatory activity plays a key role in the pathogenesis and progression of atherosclerosis in subjects with type 2 diabetes. Hence evaluation of inflammatory novel biomarkers like high-sensitivity C-reactive protein and ferritin serves as tools for cardiovascular risk prediction. Objectives to evaluate the levels of high-sensitivity C-reactive protein (hs-CRP), ferritin & glycated haemoglobin in controls and type 2 diabetic subjects and to assess the correlations if any, between fasting serum glucose, hs-CRP, ferritin & glycated haemoglobin. Materials and Methods A total number of 100 subjects were studied, comprising of 50 controls and 50 type 2 diabetic subjects. Diabetic subjects were further divided depending upon treatment modalities. Serum levels of hs-CRP, ferritin were measured by Chemiluminescense Immunoassay. Glycated haemoglobin was measured by Nephelometry. The statistical analysis was carried out using studentt test and Karl Pearsons coefficient of correlation. Results hs-CRP, ferritin & glycated haemoglobin levels were found to be significantly increased (p<0.01) in type 2 diabetic subjects compared to controls. There was highly significant (P<0.01) positive correlations existed between fasting serum glucose, hs-CRP and HbA1c. Discussion & Conclusion Elevated levels of hs-CRP and ferritin predict the future cardiovascular complications in type 2 diabetic subjects. Glycated haemoglobin serves as a simple and rapid biomarker to assess glycemic control in type 2 diabetic subjects. The current study demonstrates that higher HbA1c levels are significantly associated with elevation of hs-CRP. These results imply a significant relation between glycemic control, inflammation and cardiovascular risk. Type 2 Diabetes Mellitus, Glycated haemoglobin, High-sensitivity C-reactive protein & Ferritin
Keywords: Type 2 Diabetes Mellitus, Glycated haemoglobin, High-sensitivity C-reactive protein & Ferritin
Edition: Volume 5 Issue 6, June 2016,
Pages: 2177 - 2182
Similar Articles with Keyword 'Type 2 Diabetes Mellitus'
Downloads: 102
Research Paper, Biochemistry Science, Nigeria, Volume 3 Issue 12, December 2014
Pages: 2667 - 2669Pregnancy Complications and Mental Health Related Problems Associated With Type 2 Diabetic Patients Attending General Hospital Katsina, Nigeria
Kankia H. I. [2] | Safiyya Y. S.
Downloads: 131
Research Paper, Biochemistry Science, India, Volume 4 Issue 4, April 2015
Pages: 72 - 78Oxidative Stress and 3243 A/G Mitochondrial Dna Mutation In Maternally Inherited Type 2 Diabetes Mellitus
Utpal J. Dongre | Virendra G. Meshram | Shailesh Pitale