Abstract: Pemphigus vulgaris (PV) is a chronic inflammatory autoimmune bullous disease. PV almost always affects the mouth and it can be the initial site of presentation in 50% of cases, before skin and other mucosal sites become involved. This is a case of 60-year-old female came with the chief complaints of pain and erosion in the mouth since 1 week. On intra-oral examination solitary, erythematous, pseudomembranous plaque present over the right buccal mucosa. As the patient was diagnosed with pemphigus vulgaris, the goal of therapy was to reduce inflammatory response & autoantibody production. The patient was treated with Methylprednisolone, antifungal & antibiotic along with local anesthetic gel for symptomatic relief. PV is a serious disease, and If left untreated, it could lead to patient's death.
Keywords: pemphigus vulgaris PV, autoimmune, blistering, oral lesions, mucous membrane