Farah Khan, V. Nagulwar, S. Deshpande
Abstract: Psoriasis is distinguished by hyper-proliferation and unusual differentiation of epidermal keratinocytes, lymphocyte infiltration containing mainly of T lymphocytes. Psoriasis may be treated mainly by topical and dermal route because systemic therapy or phototherapy mainly concerns with the possible tissues toxicity and sometimes result in carcinogenicity. Beyond the various presently existing management options of psoriasis, topical therapy is the most widely used. Developed gel (4.5 % w/w Carbapol 934) Swiss albino mice give relevant result for treatment of psoriasis, without any tissue toxicity such as redness, erythematic in animal skin, as well as convulsion, tremor, circling, depression, hypothermia and mortality. Percent drug activity of Developed gel (4.5 % w/w Carbapol 934) was found to be 19.37 % which show a significant antipsoriatic effect in comparison of standard drug Derobin (1.125 w/w) 12.90 %. Developed polyherbal gel is more effective as compared to standard drug Derobin.
Keywords: Psoriasis, Derobin 1125 w/w, Developed gel 45 % w/w Carbapol 934