Mohamed Ahmed Mohamed Osman, Saadalnour Abusail Mustafa, Ihab Hamed Nourein Hamed, Faris Merghani Eltom, Shawgi Abdelrhman Elsiddig, Rabab Ali Alhag
Abstract: Objective: The aim of this study was to detect HER2/ Neu and BRCA1 expression in breast cancer using immunohistochemical methods. Methodology: A retrospective descriptive study was performed on 50 samples from patients diagnosed with breast cancer as well as 50 from benign breast tumors. HER/neu and BRCA1 expression was assessed using immunohistochemistry (IHC). Result: HER/neu was expressed in 4/50 (8 %) of breast cancer and 11/50 (22 %) of benign breast tumors whereas BRCA1 was expressed in 9/50 (18 %) of breast cancers and 7/50 (14 %) of benign breast tumors, with significance at p values of 0.045 and 0.393 respectively. Conclusions: There is insignificant association between HER/neu and BRCA1 expression and breast cancers among Sudanese patients.
Keywords: Breast cancers- Sudanese- HER/neu- BRCA