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Research Paper | Chemistry | India | Volume 6 Issue 3, March 2017
Improved Process for the Preparation of Halo Substituted Mannich Bases of Substituted Benzimidazoles
Satyanarayana Punna | I. E. Chakravarthy | M. Aswartha Umakantha Reddy
Abstract: Mannich bases are the end products of mannich reaction and are known as beta amino ketone carrying compounds. Mannich reaction is a carbon carbon bond forming nucleophilic addition reaction which helps in synthesizing N-methyl derivatives and many other drug molecules. Mannich base derivatives of benzimidazoles possess many pharmacological properties such as anti-oxidant, anti-inflammatory, anticancer, antiviral, anthelmintic and play an important role in medical field. As these drugs are clinically useful in treatment of microbial infections and exhibit other therapeutic activities also, so this encouraged the development of more potent, novel and clinically significant compounds.
Keywords: Benzimidazoles, Antimicrobial activity, Anti-fungal activity, mannich base, secondary amine
Edition: Volume 6 Issue 3, March 2017,
Pages: 1867 - 1874
Similar Articles with Keyword 'Antimicrobial activity'
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Research Paper, Chemistry, India, Volume 11 Issue 2, February 2022
Pages: 957 - 959Evaluation of Antimicrobial Activity of Some Thia-1, 3, 4-Oxadiazolophanes
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Research Paper, Chemistry, India, Volume 11 Issue 1, January 2022
Pages: 1319 - 1324Design, Molecular Docking, DFT and Antimicrobial Studies of Novel Benzimdazole Derivatives
A. Adhilakshmi | S. Darlin Quine