Research Paper | Medicine Science | Egypt | Volume 5 Issue 8, August 2016
Evaluation of Thyroid Dysfunction in Egyptian Chronic Hepatitis C Virus Cirrhotic Patients Complicated with Portal Hypertension
Waseem M. Seleem MD, Fady M. Wadea MD
Introduction Alterations in thyroid hormone regulation and metabolism are observed in cirrhotic patients with decreased
serum (T3).Objectives to investigate the relation of thyroid dysfunction to esophageal varices, portal hypertensive gastropathy (PHG)
and degree of liver dysfunction in Egyptian cirrhotic patients with portal hypertension. Material and methods study included 124
cirrhotic patients and 62 controls, patients were stratified into group I (62 patients) with esophageal varices and group II (62 patients)
with portal hypertensive gastropathy without varices, each group was classified according to presence or absence of bleeding into
subgroup A and B respectively. Grading of esophageal varices and PHG was done. Serum free T3 (FT3), free T4 and TSH levels were
measured using Electrochemiluminescence immunoassay.
Results Cirrhotic patients had significantly lower levels of FT3 than controls. Levels were not significantly differ between bleeders and
non bleeders. FT3 was significantly lower in advanced Child's classes and in patients with higher variceal and PHG grades. FT3 was
negatively correlated to oesophageal varices, PHG grades and INR. Conclusion FT3 level was negatively correlated to the degree of
hepatic dysfunction, grades of esophageal varices and PHG indicating that FT3 may be used as a non invasive predictor for esophageal
varices and PHG grading as well as degree of liver dysfunction in cirrhotic patients with or without bleeding, however, more studies
need to be done on a wider scale of patients for confirmation of sensitivity and specificity of adding FT3 to other traditional predictors
for varices as splenic size, P.V diameter and platelet count.
Keywords: thyroid dysfunction, chronic HCV, esophageal varices, portal hypertension, portal hypertensive gastropathy
Edition: Volume 5 Issue 8, August 2016
Pages: 595 - 600
How to Cite this Article?
Waseem M. Seleem MD, Fady M. Wadea MD, "Evaluation of Thyroid Dysfunction in Egyptian Chronic Hepatitis C Virus Cirrhotic Patients Complicated with Portal Hypertension", International Journal of Science and Research (IJSR), https://www.ijsr.net/search_index_results_paperid.php?id=ART2016836, Volume 5 Issue 8, August 2016, 595 - 600