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Research Paper | Genetics | India | Volume 14 Issue 1, January 2025 | Rating: 5.7 / 10
Unveiling the Protective Role of Hypoxia - Inducible Factor-1 Alpha Gene Polymorphisms (rs11549465 and rs11549467) in Psoriasis
Parampreet Kaur, Rajinder Kaur, Sunil Kumar, Dimple Chopra
Abstract: Psoriasis is a chronic inflammatory skin condition influenced by genetic and environmental factors. The hypoxia - inducible factor 1 - alpha (HIF1A) gene, which regulates cellular responses to hypoxia and inflammation, has been linked to disease susceptibility. This study explores the association of two HIF1A single nucleotide polymorphisms (SNPs), rs11549465 and rs11549467, with psoriasis risk in a North Indian population. A case - control study was conducted with 200 psoriasis patients and 200 healthy controls. Genotyping was performed using TETRA - ARMS PCR, and statistical analyses assessed genotype and allele frequencies, odds ratios (ORs), and haplotypes. Results indicated that the T allele of rs11549465 and the A allele of rs11549467 were significantly associated with reduced psoriasis risk. Individuals carrying the T/T genotype (rs11549465) or A/A genotype (rs11549467) demonstrated the strongest protective effects. Haplotype analysis revealed that specific allele combinations further reduced susceptibility to psoriasis. This study highlights the potential protective role of specific HIF1A variants against psoriasis, offering new insights into its genetic basis. These findings may support future research into targeted therapies and precision medicine approaches for managing psoriasis.
Keywords: Psoriasis, HIF1A gene, Single nucleotide polymorphisms (SNPs), Genetic susceptibility, Inflammatory skin disorders
Edition: Volume 14 Issue 1, January 2025,
Pages: 240 - 245