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Research Paper | Biochemistry | India | Volume 14 Issue 2, February 2025 | Rating: 5.9 / 10
Inflammatory Markers and Insulin Resistance: An Observational Study in Type 2 Diabetes Mellitus Patients
Arvind Kumar Gupta, Raashika Saxena
Abstract: Background: Chronic Inflammation plays a crucial role in the development and progression of type 2 diabetes mellitus (T2DM). Inflammatory markers such as C-reactive protein (CRP), Interleukin-6 (IL-6) and ferritin have been implicated in insulin resistance which is a key feature of T2DM. Objectives: In this study, we aimed to investigate the relationship between inflammatory markers (CRP, IL-6, ferritin) and insulin resistance in patients with T2DM. Materials and Methods: A hospital-based cross-sectional study included on 50 T2DM patients aged 20-65 years who underwent measurements of CRP, IL-6, ferritin and insulin resistance (HOMA-IR). Correlation analysis and linear regression were used to examine the relationships between inflammatory markers and insulin resistance. Results: The study revealed significant positive correlations between CRP (r = 0.65, p < 0.001), IL-6 (r ? 0.58, p < 0.001), and ferritin (r = 0.52, p < 0.001) with HOMA-IR. Linear regression analysis showed that CRP and IL-6 were independent predictors of insulin resistance (? = 0.43, p < 0.001 and ? = 0.35, p < 0.001). Conclusion: This study demonstrates a significant association between inflammatory markers (CRP, IL-6, ferritin) and insulin resistance in patients with T2DM. These findings support the role of chronic inflammation in the pathogenesis of insulin resistance and T2DM, and highlight the potential for anti-inflammatory therapies to improve insulin sensitivity and glucose metabolism in patients with T2DM.
Keywords: Type 2 Diabetes Mellitus, Insulin Resistance, Interleukin-6, Ferritin, CRP
Edition: Volume 14 Issue 2, February 2025,
Pages: 81 - 84