Rate the Article: Modulator Effect of XmnI Polymorphism Concerning 50 Mauritanian Sickle Cell Disease Patients, IJSR, Call for Papers, Online Journal
International Journal of Science and Research (IJSR)

International Journal of Science and Research (IJSR)
Call for Papers | Fully Refereed | Open Access | Double Blind Peer Reviewed

ISSN: 2319-7064

Downloads: 106 | Views: 328

Research Paper | Hematology | Mauritania | Volume 7 Issue 2, February 2018 | Rating: 6.1 / 10


Modulator Effect of XmnI Polymorphism Concerning 50 Mauritanian Sickle Cell Disease Patients

Ghaber Sidi Mohamed, Salem Mohamed Lemine, Kleib A-S, F. Najjar, Aminetou Mohamed


Abstract: The present study shows that the XmnI polymorphism (rs7482144) at -158 C T of G gene is well associated with increased expression of HbF among sickle cell homozygotes in Mauritania. The prevalence of homozygous and heterozygous XmnI polymorphism is respectively of 36 % and 34 %, whereas negative individuals for this polymorphism are of 30 % in the Mauritania population. This XmnI polymorphism induces increased HbF synthesis. The most found haplotype in Mauritania is the Senegalese type (77.7 %) which was described as a relative protector by the presence of HbF followed by the beninese haplotype (8.8 %), the Arab-Indian (5.5 %), the Bantu (4.4 %) and the two atypical haplotypes 1 and 2 (2.2 and 1.1 %) reflecting the multiethnic character of Mauritania.


Keywords: XmnI, sickle cell disease, Mauritania


Edition: Volume 7 Issue 2, February 2018,


Pages: 1384 - 1387



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