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Research Paper | Chemistry | India | Volume 7 Issue 7, July 2018 | Rating: 6.4 / 10
Synthesis and Characterization of Novel Trisubstituted Pyrazole Derivatives from Chalcones
K. Banupriya, Dr. R. Girija
Abstract: ABSTRACT Pyrazole moiety, being called as pharmacophore, plays an important role in many biologically active compounds and therefore represents an interesting template for combinatorial as well as medicinal chemistry. In addition pyrazoles are also used extensively as useful synthons in organic synthesis. These derivatives have wide spread biological activities such as anticancer, analgesic, anti-inflammatory, antimicrobial, antiviral, anticonvulsant and anti-HIV. The recent success of pyrazole COX-2 inhibitor has further highlighted the importance of these heterocycles in medicinal chemistry. These newly synthesized compounds were characterized by NMR,mass spectral,IR spectral studies as well as by C,H and N analyses. Several pharmacological activities like antitubercular, analgesic, anti-cancer, anti-inflammatory, antiasthmatic, antioxidant and antibacterial activities have been attributed to pyrazoles. In the present study,a novel series of pyrazole derivatives (4a1-24) were synthesized by phenylhydrazine hydrochloride with different chalcones. The starting material, chalcones were prepared by Claisen Schmidt condensation of ketones with aldehydes in the presence of sodium hydroxide in ethanol. All the synthesized compounds were characterized by IR, 1H-NMR, and Elemental Analysis.
Keywords: KEYWORDS: Chalcone, Phenylhydrazine hydrochloride, antimicrobial activity,Sodium hydroxide,Pyrazoles.
Edition: Volume 7 Issue 7, July 2018,
Pages: 468 - 472