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Research Paper | Biochemistry Science | India | Volume 3 Issue 7, July 2014 | Rating: 6.7 / 10
Prevalence of Antithyroid Antibodies in Newly Diagnosed Subclinical Hypothyroidism in Relation to Type 2 Diabetes
K. G. Sunitha, Padmini Ekambaram
Abstract: Autoimmune thyroid disorders are the commonest form of thyroid disease. The presence of autoantibodies against thyroid antigens mainly thyroid peroxidase (anti-TPO) and thyroglobulin (anti-Tg) are the hallmarks for autoimmune thyroid disease. Thyroid disorders and diabetes mutually influence each other but the role of type 2 diabetes in the development of autoimmune thyroid disease is not well studied. The study was designed to investigate whether diabetes had any role in triggering the occurrence of thyroid autoantibodies. Newly diagnosed Subclinical hypothyroid patients were categorized in relation to diabetes and their antithyroid antibodies were studied, the results revealed that diabetes was not a prime factor in the development of autoimmune thyroid disease. Moreover, the prevalence of autoimmune thyroid disease were more in female compared to male like other autoimmune disease, and anti -TPO were more common compared to anti-Tg in both male and female patients with or without thyroid disorder irrespective of being diabetic or normal. The present work can be extended to a larger population to gain a better understanding of this concept.
Keywords: autoimmune thyroid disease, thyroid peroxidase, thyroglobulin, antithyroid antibodies, diabetes Mellitus
Edition: Volume 3 Issue 7, July 2014,
Pages: 2153 - 2157